Amidation strategy for final-step α-hydroxytropolone diversification

The Strategy of Export Diversification and Economic Growth in

Today export diversification has become one of the most important economic objectives of development strategies in the developing countries. For various reasons, such as preventing instability in export prices of primary products in global markets, reducing fluctuations in exchanges of them compared with industrial goods, producing dynamic benefits resulted from exporting various goods and incr...

k - Route Diversification CSci 5980 Final Report

A Single-Step Approach to Recommendation Diversification

This paper addresses recommendation diversification. Existing diversification methods have a difficulty in dealing with the accuracy-diversity tradeoff. We propose a novel method to simultaneously optimize the user preference and diversity of k -items to be recommended.

Mini-step Strategy for Transient Analysis

Domain decomposition methods are widely used to solve sparse linear systems from scientific problems, but they are not suited to solve sparse linear systems extracted from integrated circuits. The reason is that the sparse linear system of integrated circuits may be non-diagonal-dominant, and domain decomposition method might be unconvergent for these non-diagonal-dominant matrices. In this pap...

Improved Protein Kinase C Affinity through Final Step Diversification of a Simplified Salicylate-Derived Bryostatin Analog Scaffold

Bryostatin 1, in clinical trials or preclinical development for cancer, Alzheimer's disease, and a first-of-its-kind strategy for HIV/AIDS eradication, is neither readily available nor optimally suited for clinical use. In preceding work, we disclosed a new class of simplified bryostatin analogs designed for ease of access and tunable activity. Here we describe a final step diversification stra...